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An offer in compromise is seldom affective for federal employment taxes. This is because these are in a category called "Public Trust Fund Taxes". This does not mean there was a formal trust; but that the taxes are withheld from employees and held "in trust" to be paid to the IRS and SSA quarterly.
There is very little lee way given to this category of tax debt.
As you might surmise, a tax attorney may be able to help you to obtain at least a installment agreement, and even to get the interest and penalties abated based on hardship.
Your only recouse will be based on hardship. AND the best chance of success is with the assistance of a tax attorney.
The IRS rarely abates the tax itself, when the tax is the public trust fund taxes. This i s because the tax, if federal employment taxes, is generallyl representative of taxes withheld lfrom employees, and so must be paid.
If these emplohyment taxes are for self employment, it may be a different story, but it will still require an attorney for the best chance of success.