You should issue w-2s to your employees and have them available to the employees no later than 1/31/06.
Self employed persons who work for your business as nonemployees will have 1099s issued and these, too are to be made available no later than 1/31/06. You must issue 1099 if you paid 600 or more during the tax year.
Be very careful that your workers are not actually employees by reviewing Pub 15. If they are employees rather than self employed, you are responsible to pay the employer's share of ss/medicare tax and may not issue Form 1099.