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Do you get the 'file is already in use' error message? or is it some other error message?
Copying the file here and there may conceal some malware issue, as well as a rights issue. The multiple copies you speak of could be freeing the file of a stealth virus inclusion that corrupts it.
I advise doing a thorough scan with reputable anti-virus software, of all computers that have been involved in the problem at any time. (Reputable anti-virus software would include TrendMicro, Symantec, McAfee, and among the free anti-virus suites, AVG Free and www.avast.com.)