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Running a small business is treated the same way as working for an employer for SSI purposes. It is earned income and it will reduce your SSI the same way as wages or salary from a part time employment.
If you friend occasionally sells something on e-bay or Etsy, the income will not affect her SSI benefits. But if she does it as a hobby and regularly receive income, than the income should be classified as earned. If she makes more than $400 she will be required to file a tax return and at some point social security administration will be notified.
Here are the rules for SSI: https://www.socialsecurity.gov/ssi/text-income-ussi.htm