Thank you for using just answer.
Are you saying that the POWER locks are acting up or that you cannot manually use the lock with a key in the door or both?
Ok, 2 more questions I need to ask then here:
1- Has this vehicle been broken into lately or had to be "jimmied" into because of a lockout?
2- Sounds like the ONLY time that the driver door does not lock properly is when you push the power lock button inside, do all the other doors function when you command the lock/unlock with this button?