Real Estate Law
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The Life Tenant (or her POA) and the 5 living grantees would have to sign the deed in order to transfer title to the property. The deceased grantee's executor/administrator would have to sign the deed on that person's behalf. IF no estate has been opened, then that should be done OR the deceased person's heirs at law could file a petition to determine heirship and get a court order determining the heirs at law in order for them to sign his interest over to the buyer(s).
They will need to sign the deed -- at the very least. They may also need to sign the purchase contract (if there is one).
The main issue you'll have is establishing the heirs at law of the deceased grantee in order to properly transfer title.