While most all anti-depressants can cause an effect on your sexual performance Zoloft or Paxil are the two with the least amount of side effects overall so these are the ones you should talk to your physician about. Prozac is one of the highest anti-depressants that can affect your sexual performance so this is one that you want to make sure and not take. But Zoloft is the best for avoiding any interferance with your sexual performance so if you have a need for an anti-depressant this one is the best for you to take without hindering your sexual performance and the longer you take it the more your body becomes used to it and the less chances are that it will affect you this way.
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