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Question

Our GSP came down with bacterial pneumonia (trachial test determined). He was on Bytril, but was just switched to a possibly more effective drug Chloramphenicol since the white cell count was still slowly increasing. It's now been 24 hours since the switch and he appears to feel bad in hour or two after adminstering the 4 tabs, 500 mg each (given every 8 hours). By the way he moves, looks like upset stomach. Had good diarrhea movement first time we noticed this symptom. He's had soft stool diarrhea because we're also having to syringe Hill Prescription a/p because of no appetite from the pneumonia. So our questions: Any concerns we should have with this drug? Side affects, Liver/organ toxicity? Could dose be too strong so that we need to reduce it? Our vet is closed tomorrow, so not sure what to do. Thanks.

Submitted: 112 days and 1 hours ago.
Category: Dog
Value: $15
Status: CLOSED
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Optional Information


Pet's Sex: Male
Pet's Age: 3

Already Tried:
walking him seems to help

Posted by Dr. Brian 111 days and 19 hours ago.

Info Request

Hi,

What does your dog weigh?

111 days and 18 hours ago.

Reply

Before this all started, 98 lbs. Now he is about 87 lbs.

Accepted Answer

<p>The published dose is 50 mg/kg which puts the dose your dog is taking at the recommended dosing, and in severe infections it can be given at this dose every 6 hours. Recommendations are to avoid in dogs with existing severe liver failure. Side effects include loss of appetite, vomiting, diarrhea and depression. With long term therapy there is a risk of bone marrow suppression of blood cell production, which is reversable when the drug is discontinued. People are much more sensitive to the bone marrow suppression effect of this drug, so wash your hands after handling the product. </p><p>It is difficult in these cases where the dog already has a poor appetite to know whether it is caused by the drug or the disease. Most, if not all antibiotics can cause poor appetite, vomiting and diarrhea so switching won't necessarily avoid this side effect. In general, we will give a drug at least 5 days before considering a switch to something different. </p><p>Here is a link for more reading on this drug:</p><p>http://www.petplace.com/drug-library/chloramphenicol-chloromycetin/page1.aspx</p>

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Expert: Dr. Brian
Pos. Feedback: 100.0 %
Accepts: 
Answered: 8/2/2009

Dog Veterinarian

30 years in private practice, 2008 WA State Vet of the Year

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