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Question

I have been taking mirtazapine 45 mg for about 8 months. Prior to that I was taking 30mg. I have gained about 25 lbs, which isn't neccessarily bad, however I have lost my libido completely since I have been on the medication. If I take 15 mg only, will this still help my symptoms and return my libido?

Thanks.

Submitted: 269 days and 19 hours ago.
Category: Mental Health
Value: $15
Status: CLOSED
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Optional Information

Age: 28; Male

Already Tried:
most other anti-depressants. mirtazapine works, but no libido.

Posted by Dr. Kaushik 269 days and 18 hours ago.

Info Request

Hi there,

Welcome to Just answer !

Well, like other anti depressants , mirtazapine also has sexual side effects such as decreased libido , which you are experiencing right now. I would like to ask you a few questions , kindly answer them against their numbers .

1) What is your formal diagnosis , is it Major depressive disorder ( MDD) ?

2) sINCE HOW MANY days are you taking mirtazapine ? How are your symptoms as of now , are they under control?

3) how amenable are you to changing to another drug which will take care of your symptoms and will not cause sexual side effects ?

Regards...</p>Dr. Kaushik39948.9161650116

268 days and 21 hours ago.

Reply

 

Hello,

Thanks for your help.

 

1) MDD

 

2) Over 1 year. For the most part things are fine. Remission feelings are usually one a week or so, compared to nearly constant without it. The only thing, is that sometimes I get worked up or stressed very easily. Like I have had several cups of coffee at once.

 

3) I would like to try something different. I have tried SSRI and didn't respond well. I have tried Wellbutrin, and had some trouble sleeping and didn't feel as much like eating. It is also not in the same league as Mirtazapine. It is not as effective. I am thin as it is, but mirtazapine has gotten me to a more normal weight. The intense hunger/sugar cravings are annoying, but I can deal with them. I used to like not having a libido, however it is not helping and would like it to return.

Thanks

Accepted Answer

Hi there , thanks for the reply.

Well, i agree with you that Mirtazapine is a very effective anti depressant , but like other anti depressants , it also causes weight gain and loss of libido . Since you are thin , so you are liking weight gain that you had put on ,but at the end of the day it remains a side effect of Mirtazapine , and it is not a natural way to put on weight , plus the hunger cravings associated with it are difficult to put up with and are distressing . Since you already have tried other SSRIs without much effect and currently you would want to have your libido back , so switching you over to an SSRI or an SNRI anti depressant , would be no good , as these anti depressants will also have the same side effects of loss of libido and weight gain.

So, although you have the option to reduce the dose of mirtazapine to either 30 mg first or 15 mg ( later , if 30 mg dose does not lead to return of libido), but it is not certain that reducing the dose of mirtazapine will help you regain your libido after all , so in this case , where reduction of mirtazapine dose does not lead to return of your libido , i will suggest you switch over to an anti depressant called as Stablon ( Tianeptine ) which is an SSRE ( SEROTONIN REUPTAKE ENHANCER ) , different from SSRIs and SNRIs , and the best quality about Stablon which makes it so special is that it has 3 functions combined in one drug , which are , it is an anti depressant , also is an anti anxiety drug and is a mood enhancer .
So, because of these three features it is used very effectively in MDD.Also, some researches have shown that stablon also enhances the libido , which is quite opposite to other anti depressants .

I am mentioning below a link which will throw more light on Stablon ( tianeptine).

http://www.tianeptine.com/

So, i suggest you discuss with your doctor , the use of stablon in your case , but this will come into picture , after you have tried to reduce the dose of mirtazapine to 30 mg first and looking for improvemrnt in libido , followed by further reducing of dose to 15 mg and looking for improvement of libido , but one thing you need to keep in mind that while reducing the dose of mirtazapine to regain your libido , the primary function of mirtazapine should not get compromised , so the dose of mirtazapine should be adjusted in such a way that while you regain your libido , at the same time your depressive symptoms are also being controlled on that same reduced dose .

And if your libido does not return after reducing the dose of mirtazapine to 15 mg , then you shall ask your doctor to switch you over to Stablon ( tianeptine ) and decide its dose and time of intake and get you started on it , and i am quite sure it will work for you as it will improve your libido and also control the MDD symptoms.

I wish you best of health.

I hope my answer serves your query according to your satisfaction.

Please press the GREEN ACCEPT button if you are satisfied with the answer as only then will i be credited for my service.

Regards...



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Expert: Dr. Kaushik
Pos. Feedback: 99.4 %
Accepts: 988
Answered: 5/16/2009

Psychiatry Resident

MD Psychiatry Senior Resident

268 days and 18 hours ago.

Reply

Thank you Dr. Kaushik.

 

I looked it up, and unfortnately, the U.S medical industry is run by corporate interests. The medication is not available in the U.S.

 

Any other ideas that could help? I have thought about Sildenafil, but in addition to function, I have no desire. So, taking a sildenafil I don't think would help, because the desire isn't present that would even lead to anything.

 

Thanks

Accepted Answer

Ok , and yes you are right in saying that since you lack the desire , sildenafil will not actually help .

So, in this case , you may switch over to good old Tricyclic anti depressants ( TCAs ) , as all the other SSRI and SNRI anti depressants , will have the same sexual side effects of decreased libido , while TCA s are not associated with it. Some good TCAs , that you can be placed upon are Amoxapine , Clomipramine , amitryptiline , etc . Ask your doctor to decide the dose of any one of these mentioned TCA , and place you on it , remember to ask him to keep you on a moderate dose , preferably given at night , as it causes a bit of drowsiness. But , i am quite sure adding a TCA will control your MDD symptoms , without effecting your libido and you will be able to regain your libido.

I hope this helps . Take care . For any further query , feel free to ask , i will be happy to answer you .

Regards...Dr. Kaushik39949.9259841435

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Expert: Dr. Kaushik
Pos. Feedback: 99.4 %
Accepts: 988
Answered: 5/16/2009

Psychiatry Resident

MD Psychiatry Senior Resident

268 days ago.

Reply

Hello,

I read a couple of online blogs that say Cymbalta -duloextine, doesn't have too much negative effect on Libido. It is an SNRI so, I am not sure if it would be similiar to SSRI's.

Would this be worth a try? Also, I read that people with diabetes often lack libido, could this be related to the sugar cravings mirtazapine exhibits?

Thanks

Accepted Answer

Hi there ,

Welcome back.

Well , there is no doubt that Cymbalta ( duloxetine ) , is a very effective drug used in MDD treatment , but , like SSRI AND OTHER SNRI anti depressants it also has sexual side effects such as decreased libido and impotence . I do not know which blogs you visited but i am mentioning below a few links which will throw more light on the side effects of cymbalta and among them one side effect is decreased libido.

http://en.wikipedia.org/wiki/Duloxetine#Adverse_effects

http://www.rxlist.com/cymbalta-drug.htm ( see side effects )

Well , i would have suggsted you cymbalta earlier only , but i knew that cymbalta , effexor ,which are SNRI ANTI DEPRESSANTS along with prozac, paxil , zoloft , luvox , celexa , lexapro , which are SSRI s , all these drugs cause sexual side effects , and i refrained myself from telling you these drugs as you are already struggling with decreased libido , and these drugs will be no better in improving your libido.

But it seems that you are apprehensive in trying TCAs , so in that case you have an option of getting started on Trazadone and Milnacipran combination. Trazadone is an atypical , but effective anti depressant which is taken usually at night and does not have sexual side effects , and , it has an additive sedative action, while , Milnacipran is also an SNRI anti depressant , but has least sexual side effects as compared to other SSRI AND SNRI drgs.

So, i suggest you consult your doctor and discuss the use of Milnacipran and Trazadone combination , and let him decide the doses and time of intake , but trazadone is to be taken at night only .

As far as , diabetes is concerned , yes diabetes causes erectile dysfuncion ( impotence ) , and also causes incresed appetite in which hunger cravings are seen , but this is not related to sugar cravings seen with mirtazapine.

I Hope this helps . Take care ...

Regards...

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Expert: Dr. Kaushik
Pos. Feedback: 99.4 %
Accepts: 988
Answered: 5/17/2009

Psychiatry Resident

MD Psychiatry Senior Resident

267 days and 19 hours ago.

Reply

Hello,

No, I’m still going to try to switch to TCA’s. I don’t know much about them, however when I looked them up I read a couple of them can cause decreased libido. Structurally they are the closed to mirtazapine, so I think it is the right choice. However, when I looked them up there are several to choose from. So, I was just wary of finding just the right one. I do have a bit of ocd…but mdd is the main one.

Unfortunately, I wish mirtazapine didn’t cause the other side effects. Just the last couple of days I lowered the dose to 15 mg, while there seems to be a slight increase in libido, the other symptoms come back full force. My thought process changes, ect. I exhibit more paranoia, depression, frustration ect.

I

t is like I never knew how bad my thought process was until it went away and started to come back. My past relationships suffer(last serious girl friend was 6 years ago) and it was because I was constantly feeling fizzily, a bit paranoid, mood swings, ect. With the stigma of depression, I tried Zoloft, Prozac, from an online pharmacy, but didn’t deal well w/ the side effects. Most practionars don’t understand or appreciate mental illness, so often times they misdiagnose. But I finally got serious about it about 18 months ago and got on the mirtazapine.

I can be a normal person, have the energy to talk to people, ect on mirtazapine. And like I said, the fact that it lowered my libido was nice for awhile, but not feeling like I want to progress w/ the opposite sex can be frustrating…and usually the person(s) don’t understand why. Honestly, if two people were going at it in front of me, I could read a book and really care less. So, I figure it is time to explore of options.

One other thing, I did read one blogger who said they have 4 tablespoons of honey after each meal and that help counters the sugar cravings. Until I switch to TCA’s, would this be healthy for me? Would it make me gain weight like other sweets do?

I will go back up to 30mg w/ mirtazapine until I can talk to my doctor. No libido is better than a constant thunderstorm over my head.

Thanks for your help.

Accepted Answer

Thank you ! Yes you can have honey , but not 4 table spoons , i believe 1 table spoon will do ,as you need to regulate your cravings as well . Also, i recommend you Get your fasting and post prandial blood glucose level checked ,as you have had these sugar cravings .

 

And yes go back to 30 mg mirtazapine first , and see if your libido mproves , you may afterwards even go down to 15 mg dose as well .

 

I hope this helps . No need to accept this follow up answer .Take care..

 

Regards..

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Expert: Dr. Kaushik
Pos. Feedback: 99.4 %
Accepts: 988
Answered: 5/17/2009

Psychiatry Resident

MD Psychiatry Senior Resident

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