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Question

I have an 11 yr old female Birman that had gradually lost weight from 6+ lbs. down to 4.5lbs in a two year period. The most lost was 1 lb in 4 months. She acted like she was starving and ate all the time. She had occasional diarrah and was treated by her vet for IBD. I started cooking her food like Chicken, turkey, carrotts, green beans, chicken gizzards, and fish. The vet gave her a shot of depo medrol and she had prednisone by mouth and a course of antibiotic. She started gaining weight but the loose stool returned by the 3rd week so she got another depo medrol shot. She gained up to 5.3 lbs but by the time she went back for a recheck had lost 2 ozs of that. The blood work showed a high level of eosinophilics. Her 2nd blood work shows her wbc @ 29.52, neu @23.62 and eos @ 2.54. Hypereosinophilic Syndrome seems to be the direction we are going now. The vet wants give her 50mg of Hydroxyurea for 30 days. I don't like what I am reading about this drug. What do you think?

Submitted: 284 days and 16 hours ago.
Category: Cat
Value: $30
Status: CLOSED
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Optional Information

Age: 11; Female; Breed: Birman

Already Tried:
Depo Medrol, Clavamox, Prednisone, Convenia

Accepted Answer

Hi there,

 

I am so sorry your grl was ill but very glad she has gained weight back. That is a very good sign.

 

Weight and hair loss is usually related to hyperthyroid. The cats eats great but the excess thyroid hormone burns up all the calories.

http://www.sniksnak.com/cathealth/hyperthyroidism.html

The problem is that this disorder can lead to your baby developing diabetes, high blood pressure and other ailments.

We do have excellent meds for this but is is necessary to do a T4 thyroid blood test.Any other thyroid test can be inaccurate.

It can also be related to renal issues especially if there is excess shedding because the hair becomes very dry.

Stress weakens the immune system and can lead to illness.Dental disease also depresses immunity and sends bacteria into the organs.

 

Cats are carnivores. Protein fed very often puts weight on:Please read:

 

http://www.catinfo.org/

 

If you just want to treat diarrhea add one tablespoon of infant rice cereal into her food once a day. That will cure it naturally without drugs.

 

Polycythemia is manged with Hydroxyurea so I agree you should be careful with that drug:

 

http://www.jaaha.org/cgi/content/abstract/31/5/434

 

http://www.petplace.com/drug-library/hydroxyurea-mylocel-hydrea/page1.aspx

 

There is no evidence of a tumor in your cat.

 

You may be looking at severe food allergies or IBS which is characterized by bouts of constipation and diarrhea:
http://www.marvistavet.com/html/body_inflammatory_bowel_disease.html

IBD or pancreatitis are also possiblities:

http://cats.about.com/od/diseasesandconditions/p/felineibd.htm

http://www.marvistavet.com/html/pancreatitis__feline_.html

Colitis:

http://www.marvistavet.com/html/body_colitis.html

 

Since she is gaining weight try to at her with diet for now.

 

http://www.marvistavet.com/html/body_colitis.html

Pay special attention to this section of the above link

 

TIPS FOR COLITIS

Colitis is best managed when its cause is known and specific therapy can be instituted. When this is not possible, symptomatic management is often attempted. The following are therapeutic medications and strategies that can be helpful in the treatment of colitis.

Metronidazole: This medication has anti-inflammatory properties in the large intestine as well as ability to kill harmful organisms such as Clostridia and giardia. For more information on this medication, see the link.

Sulfasalazine: This medication consists of a sulfa antibiotic bound to a salicylate anti-inflammatory. The sulfa bond protects the anti-inflammatory medication until it gets to the large intestine thus saving the anti-inflammatory effect for the disease of the large intestine. This is a very effective medication but is typically given three times a day which is an inconvenience. Cats are sensitive to salicylates thus this medication is primarily used in dogs.

Dietary Fiber: The role of fiber in colitis is confusing as there are an assortment of fiber preparations (soluble fibers, insoluble fibers, and mixtures). In general, colitis is felt to be a "fiber-responsive" disease. Fibers are broken down into nutrients for colon cells and also for food for beneficial colon bacteria.

Fructooligosaccharides (FOS): One of the prescription Iams diets as well as the Innovative Veterinary Hi Factor diet emphasizes the addition of FOS to its formulation. FOS's are carbohydrates involving fructose (fruit sugar) units attached to glucose (starch sugar) units. Most carbohydrates are digested by the bacteria of the small intestine leaving only the undigested fibers and other dregs for the teeming masses of the large intestine. FOS's are not fibers but they are digested in the large intestine (not the small intestine) in the same way that fibers are yielding the same biochemicals that fibers do. Why is this good? Tests in healthy cats indicate that this will help remove pathogenic bacteria from the large intestine and promote the growth of helpful bacteria. Think of it as an anti-crime program in the New York City of bacteria. Diets that contain FOS's may be helpful in the management of colitis.

Elimination Diet: Colitis can result from a food intolerance (an example would be lactose intolerance from which numerous people suffer). Intolerances can result from dyes, preservatives, contaminants or even natural proteins in the food. Similarly, colitis can result from an actual food allergy. The solution for these intolerances is the feeding a "pure" diet, ideally a home cooked food made with carbohydrates and proteins that are novel or new to the patient. An 8-10 week diet course is typically needed and no other chews or treats can be offered during the time of the trial. Food allergy cannot be diagnosed by blood test or skin test. At this time, response to elimination diet is the only test for food allergy or intolerance

Since itchy skin is a common manifestation of food allergy or intolerance, more detail on the subject of elmination diet can be obtained on the food allergy page.

Treating for Clostridium: Clostridial organisms are a group of anaerobic bacteria responsible for such unpleasant conditions as tetanus, botulism, and gangrene. There are Clostridial organisms that normally live in the large intestine but they do not cause any trouble unless some stressful event or diet change allows them to over grow. Once they are present in large numbers the toxins that they produce become significant and can cause colitis. (Think of these organisms as the criminal element in the New York City of bacteria. When there is a large scale blackout in the city, large scale looting occurs with these bad eggs leading the way.)

The diagnosis of Clostridial disease is complicated. A fecal smear may show the presence of Clostridial organisms but that does not mean they are producing toxin. Further tests (the "reverse passive latex antigen test" and the "ELISA" test) may be needed but the accuracy of these tests is in dispute. Often a course of a Clostridium-killing antibiotic is used as a test. Such antibiotics include: amoxicillin, tylosin, metronidazole (which has other colitis-helping properties as well), and clindamycin.

Prednisone: Prednisone is the cornerstone of treatment for Inflammatory Bowel Disease and inflammatory bowel disease must be diagnosed by biopsy. Sometimes a trial course of this medication is suggested for colitis. For more information please see the links.

SOURCE:

http://www.marvistavet.com/html/body_inflammatory_bowel_disease.html

Please let me know how she is doing. I hope all will be well.

Best wishes for her,

Terri

 

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Expert: Terri Riba
Pos. Feedback: 99.9 %
Accepts: 
Answered: 2/11/2009

Feline Healthcare Expert

Expert in feline health and behavior. 20 years experience with cats.

284 days and 15 hours ago.

Reply

She was tested for thyroid with the t4 test. I guess I really just wanted your opinion of the Hydroxyurea at the dose I was told which seemed high according to what you gave me to read. I'm afraid of not treating her with this drug but I have had nothing but bad experiences with chemo and have found these Birman cats to be very sensitive to things like thier immunizations.

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