Welcome to Justanswer.com, my name is Dustin.I'm sorry to hear about the issue you are having, I will do my best to help you resolve it.
Are these the steps you have been following to attempt changing the ink tanks?
On the epson printer itself, press the home button and select Setup > Maintenance > Ink Cartridge Replacement and press the Color button. Lift up the scanner unit.
Please try those exact steps and let me know if this works.
Dustin S.Senior Technician and Network Switching Systems Operator / Maintainer.