Hi there. We usually divide antipsychotics into two general classes, conventional and atypical. The conventional antipsychotics have been around a lot longer and were mostly used in decades past. They can be effective, but tend to carry the more worse side effects of the two. Also, these ones mainly work to block dopamine... and they're not commonly shown to treat the negative symptoms. The atypical antipsychotics are the newer ones that seem to prove more effective for the negative symptoms. These do not go without risk of side effects either, they have the possibility of causing metabolic side effects (weight gain, cholesterol disturbances, increased blood sugar, etc). However, they do show more effectiveness over those negative symptoms. It's hard to say exactly which one is the "best" for negative symptoms, it really just depends on the patient. Drug companies are constantly trying to come up with new atypical's that are more targeted for the negative symptoms, and they like to say they're newer ones may be better for negative symptoms. Some of the newest agents to come out include Saphris, Fanapt, Latuda. I've read a few reports that Latuda may be slightly more effective for negative symptoms... but again it really just depends on the patient. It's something you'll have to discuss with your physician/psychiatrist to determine what might be right for you. Good luck and let me know if I can help you with anything else.