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My name is ***** ***** I have been a Vet tech for 30+ years.
Can you post a picture of what you are seeing?
What type of food are you feeding is it plain seeds or is it sticky?
I cannot see it can you try another picture please?
I played with the Picture a bit from what I can see the Hamster looks like an Impacted cheek pouch. This is when a Hamster is a glutton and will pack food into a pocket used to store food that is in the cheek and when jammed in the pocket, it becomes impacted. In a case like this it does need to be removed because the food can rot in the cheek pouch and become infected. It will require a Vet to clean the cheek pouch out. You can see in this Video how the Vet does that:
I would love to see a Better picture of the pouches, if you can post one.