Hello, the most common reaction we see to the Vectra products are severe itching and skin irritation , and this is only in about 15% of our patients. The biggest draw back with this product is that it is much more liquid then other flea preventions.

For large dogs for Fleas only I like the Comfortis which is a pill given once a month or Advantage which is a topical ( now available over the counter)
If ticks are also a problem then Frontline Plus ( also available over the counter)

For small dogs for fleas we use Revolution which is also a heartworm preventive, comfortis or advantage. If ticks then Frontline Plus

For Cats we prefer Revolution but Advantage or Frontline work well also.

I hope this helps, please reply back if you have additional questions and I will be glad to continue helping.

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Candy