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No, it doesn't seem to bother her at all.
It is a 4 in long by 1 in strip on her back. I forgot to mention that she also has another smaller bald spot higher up on her back that is a strange shape and about 2 in wide.
She lives outdoors in a hutch when the weather is good, and she lives indoors in the cold weather.
I put pine shavings in the dropping tray below her hutch, so she's not really exposed to the bedding too much.
Also, I have noticed that she is shedding alot more than usual. And she is a mini rex.