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Any time that you have hair loss, the skin feels hot so this is not as much a concern. The skin might also feel greasy and this is different from a normal feeling.
Causes of hair loss vary.
If the cat has allergies to fleas, products, the environment or other allergens, she might lose hair. Even if you do not see fleas, it only takes one to get the cycle started.
You need to arrange for a vet visit to diagnose and treat the problem.
Let me know if you have more specific questions. I will provide all the help that I can.