With these dogs, your focus is more on treating the symptoms than curing the dog.
Here's some great information:
Therapy for Babesia is not a benign under-taking. In fact, if a dog is asymptomatic with Babesia, treatment is not worth the side effects. Further, even with treatment Babesia gibsoni, and probably the other small Babesia species, cannot be fully cleared by any of the drugs listed. Female dogs testing positive for Babesia should not be bred.
This drug is not available in the U.S. but in other countries is the most commonly used treatment. A single injection is needed and is best used on Babesia canis. Side effects include: nausea, blood pressure drop, painful injection, seizures, and some fatal reactions.
This is the only drug approved for Babesiosis in the U.S. A single dose is usually effective for Babesia canis but two given two weeks apart are needed for Babesia gibsoni and the other smaller Babesias. The injection is painful plus causes muscle tremors, drooling, elevated heart rate, shivering, fever, facial swelling, tearing of the eyes, and restlessness. Pre-treatment with an injection of atropine helps palliate these side effects.
This medication serves to block the parasite from entering red blood cells and may help minimize the symptoms of the infection. Side effects are minimal and it is given as an IV drip.
This drug is not available in the U.S. but a similar drug, Pentamidine isethionate, is. It is more effective on Babesia canis.
This drug is not available in the U.S. It is similar to malarial treatment. It is given as a series of two injections two days apart generally with marked improvement in the patient by the second injection.
A combination therapy of quinine, azithromycin, atovaquone, and/or clindamycin are promising and may become prominent in the future.
A vaccine is available against Babesia in France but only seems effective against certain strains. Vaccination is 89% effective in France. The best prevention is aimed at tick control.