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Great danes have a large range in the number of pups they have. Four pups is not that unusual, but often they have much larger litters and I know personally of a couple of 12-14 pup litters. Now with a surgical AI and fresh semen, I would expect a good litter size if it was performed with fresh semen and your female was at the right stage per testing. She is a first time breeder though and many factors during the first month of pregnancy can affect litter size such as vaccinations, deworming, extreme heat or extreme cold, even too little resources such as food or shelter can lead to the absorption of pups.
I breed rotties and my females typically have between 7 and 13 puppies in each litter. However, over the years, I have had one female that never produced more than 4 pups. My point is that some females do have smaller litters than normal. In your case, perhaps your vet sees a lot of danes from the same breeder and that line doesn't produce dogs with large litter sizes. You might call the breeder you bought your dog from and ask what size litters the mom generally produces to give you an idea of whether it may be the line or not.
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I did figure she was tested since doing a surgical AI is worthless without the testing. With her being imported, then her litter size might be smaller. I've seen a few overseas breeders send pups from small litters to the US and keep pups from mothers who produce large litters for their own breeding program. Not all overseas breeders do this though.
42 days is a little early. I would have waited until at least 50 days myself as it can be hard to see earlier than that and calcification can take until 45-49 days. The closer to the due date you are the more accurate the count will be.
Hi again. Just checking to see if you have had more testing done to determine pregnancy. Did you find my answer helpful?