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Do you know the name of the pain reliever? Was it Rymadyl or Novox?
Is she drinking more than normal? Does she have more frequent outings?
I would be worried about the pain reliever since you are not sure what it is. Some anti inflammatory type drugs can cause kidney problems. I would want to have you run an sample of urine over for testing to see if this is a a simple UTI or something being caused by the meds