It's likely to be a bit more complicated than a dietary vitamin B12 deficiency although such a deficiency is seen with maldigestion/malabsoption disorders. It locates a malabsorption disorder to the ileum - the most distal portion of the small intestine. The ultimate cause of coprophagia in adult dogs has always been elusive. Some feel that the problem is behavioral, while others are convinced there is an organic reason. Soft stools, incomplete digestion of food within the stools, evidence of steatorrhea (fat in the feces), increased stool frequency or volume, or a voracious appetite might indicate a problem with maldigestion or malabsorption. Other gastrointestinal disturbances such as inflammatory bowel disease, systemic health problems including renal failure and endocrinopathies (unlikely in an otherwise normal 4 year old, medications such as glucocorticoids (prednisone, e.g.), central nervous system diseases or any disease process that causes polyphagia (increased hunger) might lead to picas (eating non-digestibles) and coprophagia. Calorie-restricted diets, especially those that are not balanced or do not adequately satiate the dog may also lead to picas including coprophagia. Recent research has suggested that there may indeed be a medical component to the problem in some cases. In a small study of nine coprophagic dogs, all had at least one laboratory abnormality that could explain the problem. The laboratory profile included a complete blood count, complete biochemical profile, amylase, lipase, trypsin-like immunoreactivity (TLI), vitamin B12, folate, fecal fat, fecal trypsin, fecal muscle fiber, trace minerals including zinc, selenium, copper, iron, magnesium and boron, and fecal sedimentation (an ova and parasite exam). Most had borderline to low TLI (suggesting pancreatic exocrine enzyme deficiency) while others had abnormalities in folate, vitamin B12 or other nutrients.
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