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I'm assuming your mean that he had incontinence issues?
How is he acting otherwise?
Does he have access to a waterbowl at all times?
Okay...great. Thanks for the additional information. I really appreciate it.
One of the side effects to Prednisone is an increased thirst. And of course, the more they drink, the more they have to urinate.
So if this were me, I'd limit his access to the water bowl until he's done with the Prednisone. You can offer a cup or so every hour, and I would stop giving him water a couple hours before you go to bed for the night. Of course, you should also let him out right before bed, to allow him to empty his bladder.
Between limiting his water intake and stopping the water before bed, and you shouldn't have any more issues. Once he's off the Prednisone, then you can go back to allowing him to have free access to his water bowl.
I hope this helps.