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Unfortunately, newborn pups can not be treated for fleas with anything like frontline/advantage or even flea powder. Now I do know that some vets will say go ahead and sprinkle a little flea powder on the pups, but they really are too young for it. They are also too young to be bathed to remove the fleas. You can use a flea or lice comb though and comb the fleas off of the puppy. If you comb them off, you can knock them into a cup of water with soap in it to trap the fleas and keep them from jumping back off.
Any fleas that travel from the pups to mom will be killed by the frontline. Once the pups are three weeks old, you can bathe them in dawn dishwashing liquid and water leaving the lather on the pups for 5-15 minutes if possible before rinsing. This kills any fleas still left.
I would also use a flea spray around the house. Use one with an insect growth regulator in it (IGR). That will help stop eggs from hatching.
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