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Hello, JACustomer. I have been a Veterinary Nurse for over 15 years and would be happy to help you today. I'm reviewing your question right now.
1) Did the maltese penetrate her? Did they achieve a tie? 2) When did your yorkie last produce puppies? 3) Is there any reason that she is not or cannot be spayed? 4) Does she have any medical conditions of which you're aware? 5) Is she on any medication at this time?
At 13, it's not ideal for her to produce puppies. Could this potentially kill her? Yes, but I think the risk could very well be limited by requesting that your vet provide an injection to keep her from producing puppies. Typically the higher risk of puppies will be achieved from a tie, but any penetration can result in pregnancy.You do not need to contact your veterinarian immediately, but I would do so promptly come Tuesday when most clinics are open again for regular hours. Let them know that she had the opportunity to breed and that you do not want to risk her health carrying a possible litter to term. Most vets are understanding of this situation, especially if they're overseeing care for her mammary tumor.In the meanwhile, keep them from breeding again. If needed, purchase bitch britches or a similar system over the weekend to keep your male from being able to penetrate her again.
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JACustomer, please see above for my latest reply.
You're very welcome. Good luck!