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Hello. I'm sorry to hear about your dog.
This sounds like Lymphoma to me. I'm surprised they didn't get a confirmed diagnosis after the lymph node aspirates. The lethargy, weakness, decreased appetite and leg swelling all fits. When a dog has Lymphoma, they will get obstructed lymph vessels and then edema in the limbs.
I would probably get a consult with a veterinary oncologist. They can re-aspirate the lymph nodes and see if they get a diagnosis. Most oncologists will read out the slides in house and start chemotherapy at the same time. Chemo is the best way to treat Lymphoma. We get a good response rate to put it into remission. Survival times are typically ~ 12 months with a good response. This is in contrast to ~ 2 months survival times without chemo.
If you can post the x-ray, I'll take a look for you and give you a second opinion. I know it's frustrating not having an answer. I just think the aspirates were probably at a time when the cells weren't shedding or they were low cellularity samples. I'd re-aspirate asap to get an answer. If still unsure, then biopsy. It's rare to require a biopsy, though, to diagnose Lymphoma.
It definitely looks like there are some enlarged nodes under the jaw and in front of the left shoulder on those x-rays. The abdomen doesn't look too bad. There could be a mass effect in the caudal right abdomen, but it may also be the bladder. I'm not totally sure without the lateral view as well. The spleen, liver, kidneys and GI tract all look normal.
If you could post the aspirate results, that would be helpful.
Ok. I'm only seeing one lymph node aspirate and then a mammary aspirate. I would probably aspirate a pre-scapular in front of a shoulder and a popliteal behind a knee. Those are away from the mouth so we don't get conflicting results secondary to any dental disease going on.
On the lateral abdomen, there is an enlarged lymph node above the colon. I just can't imagine that this is anything but Lymphoma based on the history, physical exam findings and x-rays. I would get an oncology consult and see if they can make the diagnosis.
I would say get chemo started within 48 hours to give her the best chance of getting a response. You can do massage on the limbs to help push the fluid up and also flex/ extend each joint from the toes to the body (range of motion exercises) to help. The chemo and getting the disease into remission is going to help the most, though.