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Hi. Welcome back to Just Answer. My name is***** and I've been a veterinarian for 15 years. I'm sorry to hear about this situation with Bandit. With ingestions like this, it is important to know as close to exact as possible.
1) How many of each pill did he eat?
2) How much does he weigh?
3) How long ago did this happen?
The prednisone can definitely increase appetite in those on it. That combined with hopefully his improving with his IMHA situation provided the motivation to get the pill pock with the other medications inside of it. The risk here for him getting these pills was very, very minimal. None of these meds should interact with the prednisone nor make the IMHA situation more critical. To give some perspective with these medications, I would be willing to bet that the dog they were intended for was going to be pretty similar in size. Those medications for Jake sound like he's being managed for congestive heart failure due to a valve insufficiency. For a dog with no heart problems to get these medications at those doses, there isn't going to be any big problems that require therapy. The Lasix and they spironolactone could cause some increased urination, but other than that, there wouldn't be anything that would have me particularly concerned.