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Hi Rajesh, I'm Dr. Deb. I will do my best to assist you today. I'm so sorry for this problem with Spinach.With a platelet count this low, she is obviously at risk for spontaneously bleeding which is what's happening. In all honesty, she needs to be hospitalized and a blood transfusion given to her. I don't know if you have the facilities in India to have this done, however. I assume that your vet is trying to eliminate a tick disease which is why she's on Doxycycline. In my experience, tick diseases rarely cause the platelet count to be this low. I would be more worried about an Immune Mediated Thrombocytopenia or possibly ingestion of a rodenticide when the numbers are this low.If she has an immune mediated disease causing increased destruction of her platelets, then she needs to be on high doses of steroids (prednisone) as well as receiving a transfusion to stabilize her condition.I've seen low platelets with cancer but, again, the numbers are not usually as low as this.
I realize that my answer may not be what you want to hear but I would be doing a disservice to both you and Spinach if I were less than truthful and honest in my response to you. I hope you understand.
I also hope that this is helpful and that she can receive the care she needs. Deb
1. Increased destruction as might be seen in Rickettesial or tick diseases or auto-immune diseases such as Immune Mediated Thrombocytopenia
2. Decreased production in the bone marrow. Some sort of underlying cancerous problem might be suspected to cause this problem. It would take a bone marrow biopsy to detect such an issue.
3. Sequestration such as in the spleen. Unfortunately, this is usually associated with a cancerous process, too, such as lymphoma. An ultrasound with a needle aspirate can be helpful in making this diagnosis.
4. Rodenticide poisoning.
5. Cancer elsewhere in the boy
6. Certain drugs have triggered Immune mediated disease such as Cephalexin or some non-steroidal anti-inflammatory drugs (Carprofen).
Rajesh: Thanks for the rating; it's greatly appreciated. That's a real shame that you can't get injectable Doxycycline drugs in India. Unfortunately, it would be illegal for me to provide you with a prescription without a client/patient relationship...which means I would have to physically examine Spinach (which clearly I cannot do). There are other options to Doxycycline such as Tetracycline or Minocycline which are acceptable alternatives.As quoted from Plumbs, Veterinary DRug Handbook:1. Oxytetracycline HCl 50 mg/mL, 100 mg/mL Injection: There are many FDA-approved oxytetracycline products marketed in these concentrations. Some trade names for these products include: Terramycin®, Liquamycin®, Biomycin® (Bio-Ceutic), Medamycin® (TechAmerica), Biocyl® (Anthony), Oxyject® (Fermenta), and Oxytet® (BIVI). Some are labeled for Rx (prescription) use only, while some are over-the-counter (OTC). Depending on the actual product, this drug may be FDA-approved for use in swine, cattle, beef cattle, chickens or turkeys.2. Minocycline also is available as an injectable: Minocycline HCl Powder for Injection lyophilized for solution: 100 mg in vials; Minocin® (Triax); (Rx) I will continue to wish you the best with this situation as you struggle to treat Spinach effectively. Deb
Rajesh: Just a clarification: The Oxytetracycline drug is a veterinary labeled drug but the Minocycline is a human labeled drug...at least here in the States. I'm not sure if this is helpful information or not. Deb