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Hi, I'm Dr. Deb. I will do my best to assist you today since Dr. Peter is currently offline. Hemorrhage after attempting to remove a mast cell tumor is not uncommon especially if there was incomplete removal of it. And, depending on the size and location, it can often be difficult to completely remove....certainly a problem I might expect if a leg is involved.
I personally haven't used Protamine for this problem but I researched a veterinary database and found the following dosage:Doses of 0.5- 8mg/kg are often used...quite a large range.. More commonly 1-5mg/kg are used. The drug is given intravenously and if given too rapidly can cause acute hypotension, bradycardia, pulmonary hypertension, and dyspnea (respiratory distress). You might also consider Yunnan Baiyao (also called Yunnan BaiYao) which is a natural anti-coagulant. You can apply it directly to the skin and it can be taken orally at a dose of one capsule twice a day. I know it's available on the internet but I'm uncertain if you would be able to find it locally. A good source will be important since there are counterfeit products which may not be what they claim. These are two reliable sources:
Jing Tang herbal (tcvmherbal.com(NNN) NNN-NNNN,
A Time to Heal Herbs ( LongLink @ www.atimetohealherbs.com... )
I hope this helps and I wish you the best with this situation. Deb
Thanks for the info. Even the oncology vet at Purdue had never used protamine; sounds like the side effects are severe in canines. Anyway, my dog pulled through somehow! We didn't do anything else besides the Vit K, plasma and blood. We took him home to die, but he made it through the night, and each day, he got a little stronger. He's now almost back to normal!