Thanks for your question regarding your Great Dane girl Abbie who has a little bump below her knee. There are several things this could be including an acute dermal swelling due to a bug bite, an area of infection or even a skin mass. If it is has come up quite quickly, then it is less likely to be a mass, however we will have to keep that in mind.
If Abbie is continually licking at it, you will need to get an elizabethan collar for her today to stop this. The more she licks it, the more irritated it will get. You can also continue to apply the neosporin a couple of times per day. Given there is a chance this could be due to an allergic reaction, also try her with a little Benadryl. The typical dose is 1mg per pound of body weight up to twice daily - that means 100mg for your girl (tablets would be easiest to get this amount).
If the mass/swelling it still there on Monday - please do get Abbie seen by your local Vet. Here they can take an aspirate from the lump for cytology to get a better idea of the exact cause and nature of the swelling. Best of luck with your girl and please let me know how you get on with her over the weekend. Please just reply if you need any extra info. Don't forget to click an excited face :-D if this has been helpful.
Dr M D Edwards
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