Thank you for your post. I am sorry to hear that little Hope is having difficulties.
It is not necessisarily terrible for a 2 day old puppy to have a heart murmur. It is possible that the ductus arteriossus (a vessel that connects the pulmonary artery to the aorta in the fetus) hasn't closed all the way. IN some puppies it takes time.
However, I can't tell you it is not a significant problem either. Time will tell. If it is a very loud washing machine murmur, she may need surgery or a coiling procedure in the future to close the abbherent vessel.
the most important thing at this time is to keep Hope warm and keep her eating. This may mean that you have to tube feed her every few hours.
Here is a link for more information about raising orphan puppies. Although you may be bottle feeding her and tube feeding her, I would recommend encouraging interaction with the other puppies and the mother as she gets better and stronger.
Again, at this time, I would recommend to focus on keeping Hope warm and well fed, so she has every chance to grow and be healthy, especially if the heart murmur remains persistent and loud.
Then, she should be evaluated by a veterinary cardiologist to diagnose her underlying disease and potential therapies. Please let me know if I can help you find a cardiologist in your area.
Best of luck and my thoughts are with you and Hope. Please let me know how I can help.
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