We have had Pepperoni for 1 year in July, and Zelda for 2 months, we have yet to have them out at the same time for more than a few minutes due to the fighting. Zeldas reactions to Pepperoni are normal, a little hissing and growling but no real aggression. We swap them in and out of a spare bedroom every few days. I do not think they have ever gotten a long in the sense of it being calm when they meet. The first meeting we did the whole food at the door, etc, but since then we have not. We do not have specific play times, we play here and there. Pepperoni is a finiky eater, he is on a special urinary perscription dry food now, and we give him some wet as well but he rarely eats it. It is hard to see truely what is happening when he chases her, its very loud growling and hissing and i haven't seen blood drawn or marks on either cat, but we break it up pretty quickly. He instantly fixates and runs at her and they tussle its again very loud but once we seperate them, she is fine but he is still riled up. She goes back to normal and lays on you and etc. She likes me and my fiance but takes time to warm up to people, where Pepperoni is very much the center of attention, loves people, but loves his space too. Zelda eats everything and is not picky at all. She is polydactil. Today was the first time after 2 weeks on the medicine of him and her meeting. We want to badly for this to get better as we feel the confined room is not the best, ***** ***** big room with a large closet, a large window with a large perch, two beds, scratching post, liter box, water, etc. I can't stand the thought of losing either cat, as the attachments grow as time goes on. Obviously we have had pepperoni much longer, Zelda was my fiances cat that her mom was taking care of, we did not take her when my fiance moved in with me because Zelda used to bite and be very unaffectionate and not friendly, but her mom moved and could not take the cat, so we took in Zelda and her personality is so different now, she loves sitting on us or laying with us and being petted all night, she loves wet food which she never had, and loves treats which she never had, and just is so so happy and loving now. So it is so difficult. Our new vet is trying to help with getting Pepperonis aggression down against Zelda, but not sure what we can do.