Have Cat Questions? Ask a Cat Vet Online.
I would use something like Acepromazine to sedate a cat for grooming, but this is something you would need to get from your vet. Childrens Benadryl may get you enough sedation to groom her and is worth a shot before getting something stronger. You can start the dosing at 1 mg/lb, but can go as high as 2 mg/lb safely. I'd give it a good hour to kick in before trying to mess with her so she doesn't over ride the sedative effects.
Hope this helps, and be careful.
Well there's your problem right there! It sounds like she's probably in heat. Cats in heat are absolutely annoying. They will wander, meow constantly and often flag their tail to the side or roll and act erratic. Cats are strange creatures as they only ovulate when bred so they can stay in heat for quite some time. Unlike dogs, cats are safe to spay while in heat. I would schedule the procedure as soon as possible to make her stop acting like this.