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The Benedryl would not be advisable in this case, since it is not really a decongestant, but an antihistamine. What you can do is to steam up the Bathroom and sit with the Kitty in the steamy room for about 20 mins. This will aid in helping open the breathing passages. The next thing you can use is some Saline Nasal spray like "Little Noses Pediatric Saline Spray" This will help break loose the congestion in the nasal passages. The last thing you can do is to open a jar of Vicks Vapor Rub in the room where the kitty sleeps. Make sure it stays out of the Kitty's reach, but the Vapors should also help with congestion. I hope the Kitty feels better very soon. Joan