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Greetings,Thank you for your question. I am Dr. Su S. and I will try my best to help you.I am sorry for his symptoms.The dose varies according to the severity of infection.Total dose in a day can vary from 225-500 mg.It is to be divided in 2-3 doses.I hope this information will be helpful.If you have any query, please feel free to ask.If you are happy with my answer please click on the Excellent/Good rating. Wish his healthy life.Regards.