Hello and Thank You for using Just Answer. I am so very sorry to hear about the problems that you are having with your grandchildren. This can be a very touchy situation because parents do not like to be told how "to parent". Your grandchildren may not have had any boundaries established for them and have tantrums when they cannot get their way. They obviously have not been taught how to respect you.
Therefore what you can do in a loving. compassionate, and caring way is to approach your son one day. Tell him that you have noticed a major shift in your grandchildren's behavior since they were younger. Ask him if he has noticed a change as well. Then you can continue to explain that you were a little worried because the children are unfriendly, push you, etc. Then wait and see how he responds. If he acts like there is no problem, leave the issue alone with him. You do not want to put any blame on him or his wife. However when the children are around you, it will become your obligation to teach them how to properly respond and behave around you.
Hope this helps and provides you with some insight. Have a great day!!!