Erythrocytes(RBC) 2.95 2.97x10^6/uL
Hemoglobin 9.8g/dL 9.6
Hematocrit 28.4% 28.8%
MCV 96fL 97fL
MCH 33.3pg 32.2
MCHC 34.6g/dL 33.2
RDW 13.9 14.5
Leucocyte(WBC) 16.4x10^3/uL 13.9
Neutrophils(%) 87.3% 89.2
Lymphocytes(%) 6.9% 6.3
Monocytes(%) 4.5% 3.6
Eosinophils(%) 1.2% 0.9
Basophils(%) 0.1% 0.0
Neutrophils(absolute value) 14.3x10^3/uL 13.9
Lymphocytes(absolute value) 1.13 x10^3/dL 0.87
Monocytes(absolute value) 0.74 x10^3/dL 0.5
Eosinophils(absolute value) 0.2 x10^3/dL 0.12
Basophils(absolute value) 0.02 x10^3/dL 0.00
Platelets 348 x10^3/uL 427
MPV 8.4fL 8.3
Glucose 238mg/dL 246
Urea 37 mg/dL 76
Creatinine 1.0 mg/dL 1.0
Calcium 7.6 mg/dL 8.0
magnesium 2.1 mg/dL 1.6
total protein 6.0g/dL 6.5
albumin 3.2 g/dL 3.7
uric acid 6.7 mg/dL 8.4
TGO-AST 25U/L 35
TGP-ALT 37 U/L 45
lactate dehydrogenase (LDH) 439 U/L 1154
alkaline phosphatase 113 U/L 148
gamma glutamyl transferase(GGT) 42 U/L 64
total bilirubin 0.4mg/dl 0.4
direct bilirubin 0.2mg/dl 0.2
Na+ 133meq/L 134
k+ 4.3meq/L 4.5
chlorine 98mmol/L 100
TGP-ALT is now 22 U/L
lactate dehydrogenase (LDH) is 370 U/L
alkaline phosphatase 112 U/L
gamma glutamyl transferase(GGT) 33 U/L
ok, my father is tolerating well, but he lost weight...
Is it possible that with cycles of taxotere PSA returns to a normal value?
how much time can the cancer respond to taxotere?
Hi Dr. David,
My father made the eighth cycle of taxotere on August 23.
the blood test results are:
AST:15u/L;ALT:19U/L;ALKALINE PHOSPHATASE:123U/L and PSA comes down from 854 to 740 (slowly comes down now).
This time many fungi appeared in his mouth and he has difficulty to eat..but it's surmountable, i think.
What you think of this case (PSA increase to 2559 and decrease to 740 in 8 month)?
Can he make a stop on taxotere one or two month or is not recommended?
thanks for help
His doctor recommended a CT scan in september 5, and a new chemo cycle on september 13.
In september 13 we have a new appointement with him to see CT scan result and decided if he continues taxotere or not.
I'm curious for bone metastases because alkaline phosphatase is in normal value, but doctor does not plan a bone scan yet.
Did you now any case where taxotere kills all bone metastases?
Hi Dr David
In last chemo (September 13), blood test shows that PSA increase from 740 to 880.
Dr said me: "Don't be in panic, the rise is not significant.."
But it's obvious that i'm in panic..
results of CT scan reveals that the disease at the top of the trunk almost disappeared (subclavicular adenopathy and two paratracheal adenopathy), but also reveals two new sites of bone metastasis (left arms and lumbar spine) and a little increase of some iliac adenopathy.
liver and lungs are both free of cancer.
the doctor planned more 3 session of taxotere..no more..after that he said that he will take a new medicine (now introduced here in hospitals) at home..i don't now the name of this medicine but he saids that is a medicine "of first line/option" as taxotere but best tollerated.
I now that in last CT scan (january) the value of PSA was the same (884) and that this value increase until 2559 and now decrease to 880...that signify that taxotere did much work, and maybe the result is not so bad but...
What do you think?
Thanks for help
Hi Dr David,
I know that usually the chemotherapy doctors will do 8 or 12 cycles of taxotere or even longer if the patient is tolerating it well, but the question is after 12 cycles we can tried a new agent a period of time, and after this period the patient can take taxotere again if PSA increase? It's usual to do this or not?
Another question is..because PSA increase in last cycle (740 to 880), we can expect that PSA only rise now or PSA can comes down with taxotere yet?
He has only a new appointment to his doctor to do a new cycle of taxotere on october 4, and i' m curious to know those things..
I talked with the doctor by phone. I said me that the next agent is chemotherapy of second line and tomorrow he will begin this cycle...next week again (one time per week) and the third week he rest. I don't know the name of this agent.. but what worry me is that the new agent is yet a "second line chemo".
the CT scan show that iliac chain adenopathies decreased significantly (from 32x25mm to 24x17) and adenopathy of the hepatic hilum decreseaded too (from 34x29mm to 22x18).
We also see some subcarinal adenopathies and pre vascular adenopathies that were not previously present.
Last PSA was 998.
Do you think that chemo of second line is the best solution?
No, the neuropathy is not getting worse..Yes PSA is very less (the biggest value was 2559!)
I think that is due to PSA value...in the last two cycle is coming up (slowly) from 740 to 880 then 998..and because the development of new adenophaties (< 1cm) and new sites of metastases bones..
I think that is due to PSA value...in the last two cycle of taxotere is coming up (slowly) from 740 to 880 then 998..and because the development of new adenophaties (< 1cm) and new sites of metastases bones..
I'm afraid to try it (chemo of second line) now, and after that therfe will be no more chances (because chemo of third line doesn't exist) ...and i think is too early to second line...I only understand this, if the doctor thinks that we can reduce lymph nodes until 1cm or reduce PSA to 200 or 300...
What is your opinion?
My father made today first cycle of jevtana.In last 15 days without treatments PSA rise from 998 to 1083.
Today Hemoglobin was 8.6g/dL and he mades a blood transfusion.
How many cycles of jevtana can a man do in maximum?
Can jevtana decrease PSA to a normal value?
And after jevtana we have the option of zytiga or this drug is less eficient?
My father is now with many bone pains ..His Dr prescribed 32mg of hydromorphone daily.
While we waiting for zytiga he doesn´t prescribed other chimio..but since we are waiting (1month) alkaline phosphatase rise from 132 to 164 and PSA rise to 1400.
We don´t know how many time zytiga can take to get to hospital (the request has been done last month)...
Did you agree that my father is now only on prednisona and hydromorphone for pains? Why dr doesn't try something else while we are waiting?What is your opinion?
have you ever see alkaline phosphatase values so high?
In oporto and lisbon we have one.
what did you think of zytiga?..i already read much things, some goods or very goods saying that zytiga can kill bone metastases and others saying that zytiga doesn´t works for much patients..
PSA of my father is now 1975. We are waiting for zityga...I think only in January 2013...and PSA rise 170 in a week...However, alkaline phosphatase drop from 165 to 150 U/L...some hope...
A friend of family with head cancer was advised by 2 oncologists to eat anona (annona squamosa). She did not chimio.
What is your opinion about anona?
I found in magazine Nutrition and cancer (June 2011) an article that explains that anona inhibit tumor growth..
Did you have some experiences with patients who eats anona?
My father started zytiga 2 weeks ago. PSA was 2200, LDH: 1000 and phospatase alkaline:215. Much pain on left femur bone.
Today he makes blood control.
I don' t know PSA value, because Dr, say that he request PSA only once time per month, but LDH rise to 1400 and phosphatase to 240 (the last rise was from 150 to 215).
Liver functions still good (AST:18;ALT:25).
Two weeks ago, Dr said that probably Zytiga not works imediatly.
Can we deduce that Zytiga is not working with this bad blood results?
My father mades in February 1, a new test blood: alk phos decrease from 240 to 140; LDH from 1400 to 1164 and PSA from 2200 to 2000 (since January 16 the day of last blood test).
Finally we can say that zityga is working? What do you think?
his doctor says that is too early and we don't say that yet.
Things are complicated...he is now in hospital because the last blood test of February, 1 reveals urea (80 mg) and creatinine (2,5). Today February 4, new blood test: creatinine 2,1 and urea (91mg).
Doctor say that the case is a Kidney failure due maybe by zityga and decide to stop zytiga.
I don't understand why creatinina decrease but urea rise. Are those levels are in dangerous range??