My daughter began menstruating when she was 10yrs old. Around this time she began experiencing pain in her legs and around the knee regions (which doctors described as growing pains) and she has intermittently continued to have this pain over the ensuing 16 years. She developed severe glandular fever in 2003. In 2006 she was told she had ovarian cysts but her presentation did not meet the criteria for polycystic ovarian disorder (she had about 9 cysts). Between 2003 to the present time she consistently and annually gets some sort of infection -tonsolitis, bronchitis, flu; she experiences explosive diarrhea and intermittent constipation; bloating and distention of the stomach (which she believes is related to a lactose intolerance); mouth ulcers; headaches, and dry itchy skin. In 2006 she a serum globulin level of 38. A recent blood test this week indicates the gobulin level is now 42 and her doctor has requested more liver function tests in 5-weeks and possibly a protein electrophoresis test. Previous tests have cleared her for HIV, hepatitis and celiac disease. I understand the normal range for globulin is 25-35 and that (at least 5%) of people will fall beyond "normal ranges" and be healthy- so high values are not necessarily indicative of a diseased state - but I could not find any information regarding what level of globulin signals a need for concern? I am somewhat concerned, as there is a family history of multiple myeloma, amyloidosis, myoprofliferative disease, leukemia and lupus (SLE). My son recently had a malignant melanoma removed (dysplastic naevus syndrome) and I have SLE. My daughter does not experience several of the features of SLE (skin rash, hair loss, cold sensitivity) - do you think she should be tested for this?
Was told the growing pains would go away in time (but they have remained - intermittently).
Penicillin/antibiotics for the constant infections. Forgot to mention, my daughter developed bulimic behaviour around 18yrs old which lasted at least 3/4yrs - she states this behaviour ceased about 4yrs ago.
Hello, this is Dr. David. I have read your question and am ready to help.
multiple myeloma is rare in young people, globulin is a generic blood protein and a specific M blood protein is elevated in multiple myeloma patients.
I would agree with testing her for SLE and even checking for a gluten allergy in her bowels.
as well as a thyroid level.
the serum protein electrophoresis will tell if she has a M spike or any spike at all.
good luck to her and you.
let me know if you have any questions
Experienced Oncology Physician, Trained in NYC, Ready to help.