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The uterus has a lining, the endometrium (endo) which is shed every month when we have our periods. After a woman has gone through menopause the endo should be very thin. A thickened endo can be a sign of cancer or a pre-cancerous condition, known as hyperplasia. The only way to know for sure which it is it for a sampling to be done. We typically perform a hysteroscopy, where we look into your uterus with a microscope to see where the biopsy or tissue sampling should be taken. At the same time a D&C can be performed.
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So yes, you should have your thickened endo evaluated. Discuss having a hysteroscopy so that nothing will be missed, which can happen if only a D&C is performed.