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I am sorry that your niece is so miserable.
However, it is unclear what information you are seeking
Are you asking whether the usual treatment is to ride it out, as advised by her doctor?
Do you know whether the testing done at Mayo Clinic identified the specific virus?
I had asked for some clarification and have not heard back.
If you are asking whether the usual treatment is to “ride it out”, the answer is usually yes, although it is dependent upon the specific virus that caused the infection. Antiviral medicines are only effective against a few specific viruses, such as herpes simplex virus. For most of the viruses that can be the cause of this presentation, there is no medicine that directly treats the virus, so the only option is to “ride it out”. Actually, I do not like to use that term, but prefer to say that treatment involves supportive care, but the essence is the same.
If you can get any information on the specific virus, then I can be more specific in the answer.