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Dr. SH
Dr. SH, Physician
Category: Neurology
Satisfied Customers: 8684
Experience:  Doctor of Medicine
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While both Opioids and can put a patient into sleep state if

Customer Question

While both Opioids and GHB can put a patient into sleep state if taken at high dose... isn't it true they act via different mechanisms (cns depression vs GABA respectively) and so administering them concurrently will not necessarily compound this potential for sleep?
Submitted: 22 days ago.
Category: Neurology
Expert:  Dr. SH replied 22 days ago.

Hi there.
Thank you for your question.
I will be helping you out with your concerns today.
I am sorry to hear about your problem.

Expert:  Dr. SH replied 22 days ago.

What kind of opioids are you planning to use or referring to?

Please let me know.

Customer: replied 22 days ago.
patient has been prescribed either codeine, dilauded, or opium tincture.
Customer: replied 22 days ago.
at Equianalgesic doses
Expert:  Dr. SH replied 22 days ago.

I would not recommend using these opioids with GHB as it can enhance drowsiness and sleepiness even though that they act by different mechanisms.

So even though they act by different mechanisms since both of them can cause drowsiness or sleepiness, taking both together will worsen the problem.

Let me know if you have more questions.
Please rate me by clicking on one of the rating options at your end as that is the only way I am credited on here for helping you out.
Kindest regards

Customer: replied 22 days ago.
since they act on different pathways,
if opiate dose has a sleep inducing level of 3,
and ghb dose has a sleep inducing level of 3,
then both adminstered together will still only have a sleep inducing level of 3.
It certainly wouldn't be 6 right? maybe up to 4?
Expert:  Dr. SH replied 22 days ago.

Yes I agree it would be around 4 or 5 but not 6 I agree.