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Hi Steve. Peripheral edema is one possible side effect of the Eliquis. However, there is a whole list of other possibilities ranging from the innocuous such as venous insufficiency to the very serious such as heart or kidney failure. I would suggest you have the limb examined while there is swelling and tenderness and have a doctor provide you with a diagnosis so you can formulate an appropriate plan for dealing with it.
Hi Steve. Let me know if you have any additional questions.