Hi, this is Neuro Doctor, an American Board Certified Neurologist with vast clinical experience, and I am very glad to help you with your question.
If you want to try natural supplements like the ones mentioned above then it is better you try the combination of all 3 above because such combination will give you best benefits. All these 3 natural supplements (Glucosamine, Chondroitin, and Methylsulphonylmethane) have independent protective action on the joint and cartilages. They are required for the optimum growth of cartilage and joints. So taking all 3 of them will improve your chances of obtaining maximum benefit, so taking all 3 of them together is preferred and such combinations containing all of the above mentioned 3 joint supplements are considered as the better combinations.
Please let me know if you have any further questions. And if you feel you have received the answer to your question please rate me excellent to compensate me for the time and effort put by me in answering your question.