Welcome to Justanswer.com, my name is ***** ***** I will do my best to assist you.
Issues like this can be tough to repair, normally a secure remote connection is warranted, where I can connect to your computer and try to repair the issues in person. Would you like to try that method of support?
Also, can you clarify whether your office 2010 has ever worked since you upgraded to windows 10 ? And if so, when was the last time it was working.