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Hi, my name is***** of these cars use the same M112 engine it just that the 2001 is a smaller displacement engine than the 2005. The M112 engine was an excellent engine for Mercedes. As long as the car was serviced regularly the engine should last well into the 400k km range. I personally like the W211 model over the W210. It comes down to personal preference. The W211 is more advanced but will also be more expensive to repair. Both cars are exceptionally stable on the road. In the long run, the W210 will be less expensive to maintain.
Let me know if you have any questions.