Have Mental Health Questions? Ask a Psychiatrist Online
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Well, you see many individual studies have shown that clozapine ( which is considered as a last resort as a medication to manage schizophrenia ) has been associated with increased risk of sudden death due to heart attack or stroke in those who take it. Also it may cause serious and potentially fatal blood disorder called as Agranulocytosis. So. yes although one does question its efficacy in intractable cases of schizophrenia but it does come with a high risk of serious side effects one of which is death. So, the use of clozapine should be done by the psychiatrist taking into consideration risk: benefit ratio with the use of this drug and it shall be decided to use it if its use has more benefits than the risk associated.
I am linking two links below which shall give you more insight into this issue.
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Yes i have prescribed this medicine before but i am usually reluctant in prescribing it due to the mentioned side effects and since you know that it is used in cases where other medications have failed so one has to weigh it's benefits vs it's disbenefits before usage plus regular blood work up is a must while it is being used.