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You should have a trauma-focused cognitive-behavioral therapy (CBT). If you prefer medications to the psychotherapy. You should have medication (a selective serotonin reuptake inhibitor (SSRI) or serotonin-norepinephrine reuptake inhibitor (SNRI). As an example, paroxetine can be started at 20 mg/day orally. If minimal or no clinical response is seen after three to four weeks, increased doses in 10 to 20 mg/day increments can be tried, up to 60 mg/day. Although there are fewer studies assessing the efficacy of serotonin-norepinephrine reuptake inhibitors (SNRIs) than SSRIs in PTSD, two randomized trials found venlafaxine extended-release (ER) to be more effective in reducing PTSD symptoms than placebo. We suggest adjunctive use of an atypical antipsychotic for PTSD symptoms resistant to SSRIs/SNRIs. As an example, start risperidone at 0.5mg orally, increase after five to seven days if the response is inadequate up to 4 mg/day. If no clinical benefit is seen after two to three weeks of treatment at the maximal tolerated dose, gradually discontinue the medication. We suggest trauma-focused CBT as an adjunctive treatment in patients with PTSD who have only responded partially to an SSRI or SNRI. We suggest treatment with prazosin for patients with PTSD who experience sleep disruption or nightmares or other PTSD symptoms. This medication can be used alone or as an adjunct to an SSRI or SNRI.