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Hello and thank you for using JustAnswer. Mirtazapine is meant to be taken at night because it can cause drowsiness and Zantac can be taken at night as well if you have acid reflux while you sleep because of the lying down position, although it may be best to take Zantac before or after meals for acid reflux. There are also no listed interactions between these two medications, so you can take them safely together as well.
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