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Hello and thank you for using JustAnswer. It would be unwise to continue smoking Marijuana while on the Latuda because Marijuana is a psychoactive substance and its interaction effects with the Latuda are unknown given that Marijuana is illegal so studies on its interaction with other medications are sparse. The use of these two strong substances could cause your Bipolar symptoms worsen or possibly can cause psychotic symptoms like Hallucinations and Delusions. So to be safe it would be best to refrain from using Marijuana while on the Latuda