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Hello and thank you for your question. Postural tachycardia syndrome or POTS can have numerous causes including genetics, viral illness, gastrointestinal issues, diabetes, obesity, anxiety/panic, etc...so yes an individual with Bipolar Disorder who is not on medications can develop POTS for numerous reasons independent of the medications or the Bipolar Disorder. I would recommend going to a cardiologist for treatment as sometimes a change in diet and daily activity can be enough to reverse the symptoms of POTS. And then if that fails, medications can be necessary like Fludrocortisone, Proamatine, or a Beta Blocker can help control the symptoms of POTS.