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Hello and thank you for your question. May I ask, how long exactly have you been taking the Seroquel in totality?
Thank you for your response. Because you have not been on the Seroquel for that long of a period of time and you were on a low-moderate daily dose, the withdrawal period should have only lasted 7-14 days. I would have to agree with your doctor that this could be symptoms of a physical disorder or possibly symptoms of an undiagnosed mental health disorder as it is less likely you are suffering from withdrawal.
Hydroxyzine is a first generation anti-histamine and while 150mg/day is a high dose the only major impact on you would be increased sedation/drowsiness. It is a very safe medication to take for the long-term and at this dose, but I would not recommend combining it with other sedative medications or substances (e.g. alcohol)
Both those medications are sedative, so the drowsiness/sedation factor is going to be significantly increased for you. But because you are taking Alprazolam I am assuming you have anxiety/panic issues, so it is likely that you are suffering from anxiety/panic and not withdrawal with the Seroquel because Alprazolam is an addictive medication so eventually your body does become tolerant to the dose, this is why people have to steadily increase the Alprazolam (and other benzodiazepines) to garner the same effect; this occurs with all addictive medications and substances unfortunately.
I hope this answers your questions and gives you some guidance on this issue. Please let me know if you have any questions or concerns as I am happy to assist and support you regarding this issue.
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