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Hello and thank you for your question. It truthfully depends, may I ask which antidepressant are you referring to, how long did you use it for, and at what dose?
Okay because you took such a high dose of the Effexor and for a long period of time most likely it will not work again for you as you developed a tolerance unless you add an augment like abilify. But your best bet would be to switch to another antidepressant.